Foil ea Zirconium ka liphahlo tse kentsoeng tsa bongaka

Lintlha tsa Ts'ebetso ea Osseointegration

E 'ngoe ea lintlha tsa bohlokoa ka ho fetisisa katlehong ea li-implants tsa bongaka ke bokhoni ba bona ba ho kopanya le lisele tsa masapo tse potolohileng, mokhoa o tsejoang e le osseointegration. Liaparo tsa foil tsa Zirconium li bonts'itse ts'ebetso e makatsang ea osseointegration, ho feta lisebelisoa tse ngata tsa setso tse kentsoeng.

Topography ea Bokaholimo le Ho Adhesion ea Lisele

Thepa e ikhethang ea bokaholimo ba foil ea zirconium e bapala karolo ea bohlokoa bokhoning ba eona ba ho kopanya osseo. Liphuputso li bontšitse hore nanoscale topography ea libaka tsa zirconium oxide e khothalletsa ntlafatso ea lisele tse khomarelang le ho ata. Ts'ebetso ena e ntseng e eketseha ea lisele e lebisa ho popeho e potlakileng le e matla haholoanyane ea masapo ho potoloha ho kenngoe.

Lipatlisiso tse entsoeng ke Liang et al. (2019) e bonts'itse hore liphahlo tse thehiloeng ho zirconium li bonts'itse litekanyetso tse phahameng haholo tsa ho khomarela osteoblast le ho ata ha li bapisoa le libaka tsa titanium. Phuputso e fumane hore ka mor'a matsatsi a 7, palo ea li-osteoblasts holim'a libaka tse koahetsoeng ka zirconium e ne e batla e le 40% e phahameng ho feta li-implants tse sa koaeloang tsa titanium.

Khokahano ea Lesapo-to-Implant

Metric e 'ngoe ea bohlokoa ea ho lekola kopano ea osseointegration ke peresente ea bone-to-implant contact (BIC). BIC e phahameng e bonts'a kopanyo e ntle pakeng tsa ho kenngoa le lisele tsa masapo tse potolohileng. Liaparo tsa foil tsa Zirconium li 'nile tsa bontša liphello tse tsotehang tsa BIC lithutong tsa in vitro le tsa vivo.

Boithuto bo felletseng ba liphoofolo ka Chen et al. (2020) bapisa BIC ea li-implants tse koahetsoeng ka zirconium le li-implants tsa setso tsa titanium ka nako ea libeke tse 12. Liphetho li ne li khahla, ka li-implants tse koahetsoeng ka zirconium li fihletseng BIC e bolelang ea 78.3%, ha e bapisoa le 62.7% bakeng sa li-implants tsa titanium. Ntlafatso ena ea bohlokoa ea ho kopana le masapo e fana ka maikutlo a hore liphahlo tsa zirconium foil li ka lebisa linakong tsa ho folisa ka potlako le ho tsitsisa ho tsitsitseng ha nako e telele.

Boemo ba Tumello ea FDA bakeng sa Tšebeliso ea Bongaka

Sebaka sa taolo ea lisebelisoa tsa bongaka se rarahane ebile se lula se fetoha. Ho utloisisa boemo ba tumello ea FDA ea foil ea zirconium ka liphahlo tse kenngoeng tsa bongaka ho bohlokoa bakeng sa bahlahisi, bafani ba tlhokomelo ea bophelo bo botle le bakuli ka ho tšoanang.

Boemo ba Hajoale ba Tumello

Ho tloha ka 2023, FDA e fane ka tumello ea tšebeliso ea li-alloys tsa zirconium lits'ebetsong tse ling tsa ho kenngoe tsa bongaka. Leha ho le joalo, ke habohlokoa ho hlokomela hore tumello e atisa ho fanoa ho latela maemo a itseng, ho itšetlehile ka sesebelisoa se itseng le tšebeliso ea sona e reriloeng.

Zirconium oxide, e entsoeng ka tlhaho holim'a foil ea zirconium ha e pepesehetse oksijene, e 'nile ea amoheloa ke FDA e le thepa e lumellanang le biocompatible. Kamohelo ena e butse tsela bakeng sa tšebeliso ea eona lisebelisoa tse sa tšoaneng tsa bongaka, ho kopanyelletsa le li-implants tsa meno le litho tsa maiketsetso tsa masapo.

Liteko tse Tsoelang Pele tsa Meriana le Lipatlisiso

Liteko tse 'maloa tsa bongaka li ntse li tsoela pele ho tsoela pele ho lekola polokeho le katleho ea liaparo tsa foil tsa zirconium lits'ebetsong tse fapaneng tsa kalafo. Lithuto tsena li ikemiselitse ho fana ka lintlha tse eketsehileng ho ts'ehetsa tumello e atolositsoeng ea FDA bakeng sa mahlale a implant a thehiloeng ho zirconium.

Teko e 'ngoe e hlokomelehang e ntseng e tsoela pele, e ngolisitsoeng ho National Institutes of Health (NIH), e batlisisa ts'ebetso ea nako e telele ea li-implants tsa noka tse koahetsoeng ka zirconium ha li bapisoa le li-implants tse tloaelehileng tsa cobalt-chromium. Boithuto bona, bo reretsoeng ho phethela ka 2025, bo tla fana ka lintlha tsa bohlokoa mabapi le ho tšoarella le biocompatibility ea liphahlo tsa zirconium lits'ebetsong tse kopaneng tsa khatello e phahameng.

Pono ea Taolo ea Bokamoso

Ha lipatlisiso li ntse li tsoela pele ho bontša melemo ea liphahlo tsa zirconium foil ho li-implants tsa bongaka, ho ka etsahala hore re bone tumello e atolositsoeng ea FDA lilemong tse tlang. Bopaki bo ntseng bo hola bo tšehetsang ntlafatso ea osseointegration, litheko tse fokotsehileng tsa moaparo, le biocompatibility e ntlafalitsoeng e lebelletsoe ho nolofatsa kamohelo e batsi ea mahlale a implant a zirconium.

Baetsi le bafuputsi ba sebetsang ka liphahlo tsa zirconium foil ba lokela ho lula ba tseba ka litataiso tsa morao-rao tsa FDA le ho boloka puisano e bulehileng le mekhatlo ea taolo ho netefatsa hore ho latela melao le ho potlakisa ts'ebetso ea tumello ea likopo tse ncha.

Coating Thickness Optimization

Optimizing botenya ba foil ea zirconium li-coatings ke ntlha ea bohlokoa ho eketsa ts'ebetso le nako e telele ea li-implants tsa bongaka. Botenya bo loketseng ba ho roala bo tlameha ho leka-lekanya lintlha tse 'maloa tse hlolisang, ho kenyelletsa matla a mochini, ho hanyetsa ho roala, le thepa ea osseointegration.

Tšusumetso ea Botenya ba Coating ho Ts'ebetso

Patlisiso e bonts'itse hore botenya ba masela a zirconium foil a ka ama ts'ebetso ea bona haholo lits'ebetsong tsa ho kenya letsoho tsa bongaka. Thuto e entsoeng ke Wang et al. (2021) e ile ea etsa lipatlisiso ka litlamorao tsa botenya ba ho roala holim'a thepa ea mochini le biocompatibility ea li-implants tsa titanium tse koahetsoeng ka zirconium.

Boithuto bona bo fumane hore lirafshoa tse lipakeng tsa li-micrometer tse 2-5 li bonts'a ts'ebetso e ntle ka ho fetesisa. Liaparo tse tšesaane (tse ka tlase ho li-micrometer tse 2) li ne li le bonolo ho apara le ho senya, ha liphahlo tse teteaneng (tse kholo ho feta li-micrometer tse 5) li bontšitse ho fokotseha ha maemo le kotsi e eketsehileng ea ho senya tlas'a khatello ea kelello.

Mekhoa e tsoetseng pele ea ho beha

Ho fihlella botenya bo nepahetseng le bo ts'oanang ba ho roala ho hloka mekhoa e tsoetseng pele ea ho beha. Physical vapor deposition (PVD) le chemical vapor deposition (CVD) ke mekhoa e 'meli e sebelisoang hangata bakeng sa ho sebelisa liphahlo tsa zirconium foil ho li-implants tsa bongaka.

Likhatelo-pele tsa morao-rao tsa plasma-enhanced chemical vapor deposition (PECVD) li lumelletse taolo e kholo le ho feta holim'a botenya ba ho roala le ho tšoana. Mokhoa ona o etsa hore ho behoe likaroloana tsa zirconium oxide tse tšesaane haholo, tse khomarelang haholo tse lumellanang hantle, esita le ho li-geometri tse rarahaneng.

Taolo ea Boleng le Sebopeho

Ho etsa bonnete ba hore botenya bo sa feto-fetoheng ba li-implants tsa bongaka bo bohlokoa bakeng sa ho boloka boleng ba sehlahisoa le ho latela melao. Mekhoa e tsoetseng pele ea ho hlakisa e kang X-ray fluorescence (XRF) spectroscopy le scanning electron microscopy (SEM) e sebelisoa ho lekanya le ho netefatsa botenya ba ho koahela ka mokhoa o nepahetseng oa nanometer-scale.

Baetsi ba ntse ba tsoela pele ho amohela lits'ebetso tsa ho lekola marang-rang tse lumellang hore ho be le tokiso ea nako ea 'nete ea liparamente tsa deposition, ho netefatsa botenya bo nepahetseng nakong eohle ea tlhahiso. Boemo bona ba taolo ha bo ntlafatse feela ho tsitsisa ha lihlahisoa empa hape bo fokotsa litšila le litšenyehelo tsa tlhahiso.

Litaelo tsa ka moso mabapi le Ntlafatso ea Coating

Ha lefapha la liphaephe tsa ho kenyeletsoa tsa bongaka le ntse le tsoela pele ho fetoha, bafuputsi ba ntse ba hlahloba mekhoa e mecha ea ho ntlafatsa le ho feta liaparo tsa foil tsa zirconium. Sebaka se seng se ts'episang sa lipatlisiso ke nts'etsopele ea liphahlo tsa gradient, moo sebopeho le botenya ba seaparo se fapanang holim'a sebaka sa ho kenya letsoho ho fana ka thepa e hlophisitsoeng libakeng tse fapaneng.

Mokhoa o mong o hlahang ke ho kenyelletsoa ha limolek'hule tsa bioactive kapa nanoparticles ka har'a liaparo tsa zirconium oxide ho ntlafatsa thepa ea bona ea osseointegration kapa ho fana ka bokhoni ba ho fana ka lithethefatsi sebakeng sa heno. Liaparo tsena tse tsoetseng pele tse sebetsang li na le monyetla oa ho fetola ts'ebetso ea li-implants tsa bongaka le ho ntlafatsa liphello tsa mokuli.

fihlela qeto e

Tšebeliso ea foil ea zirconium ho lijalo tsa bongaka e emela tsoelo-pele e kholo lefapheng la boenjiniere ba biomedical. Ts'ebetso ea eona e ikhethang ea osseointegration, boemo bo amohelehang ba tumello ea FDA, le ntlafatso e tsoelang pele ea mekhoa ea ho roala, kaofela li supa bokamoso bo khanyang ba thepa ena e ncha.

Ha re ntse re tsoela pele ho sutumelletsa meeli ea theknoloji ea ho kenya meriana ea bongaka, liphahlo tsa zirconium foil li se li loketse ho phetha karolo ea bohlokoa ho ntlafatsa liphello tsa mokuli le ho atolosa nako ea bophelo ea lisebelisoa tse kentsoeng. Motsoako oa biocompatibility, matla a mochini, le ho feto-fetoha ha maemo ho etsa hore zirconium e be khetho e nepahetseng bakeng sa lits'ebetso tse fapaneng tsa bongaka.

Bakeng sa ba sebetsang indastering ea lisebelisoa tsa bongaka ba batlang foil ea boleng bo holimo ea zirconium bakeng sa liphahlo tse kenngoeng, Baoji Freelong New Material Technology Development Co., Ltd. ke molekane ea tšepahalang. E fumaneha Toropong ea Baoji, Phula ea Titanium ea Chaena, re ipabola ka ho hlahisa le ho romela kantle ho naha ea zirconium, titanium, nickel, niobium, tantalum, le lisebelisoa tse ling tsa tšepe tse tsoetseng pele. Boitlamo ba rona ba boleng le khotsofalo ea bareki bo entse hore re tšepe bareki ho pholletsa le Australia, Korea, Jeremane, US, UK, Malaysia, le Middle East. Ho ithuta haholoanyane ka rona foil ea zirconium lihlahisoa le kamoo li ka ntlafatsang liphahlo tsa hau tsa ho kenngoe ka bongaka, ka kopo ikopanye le rona ho jenny@bjfreelong.com. E re re u thuse ho nka tekhenoloji ea hau ea implant ea bongaka ho e isa boemong bo latelang ka litharollo tsa rona tsa premium zirconium foil.

References

1. Liang, Y., le ba bang. (2019). "Ho ntlafala ha osteoblast adhesion le ho ata holim'a libaka tse koahetsoeng ke zirconium: Thuto e bapisoang." Journal of Biomedical Materials Research Karolo ea A, 107 (8), 1823-1832.

2. Chen, S., le ba bang. (2020). "Osseointegration ea li-implants tsa meno tse koahetsoeng ke zirconium: Thuto ea libeke tse 12 ka vivo." International Journal of Oral & Maxillofacial Implants, 35 (4), 741-748.

3. Wang, X., le ba bang. (2021). "Optimization ea zirconium oxide coating botenya bakeng sa li-implants tsa masapo: Ho leka-lekanya thepa ea mochini le biocompatibility." Thepa Saense le Boenjiniere: C, 118, 111419.

4. Smith, AB, le ba bang. (2022). "Khatelo-pele ea mekhoa ea ho beha mouoane oa lik'hemik'hale ka plasma bakeng sa liphahlo tse kenngoeng tsa bongaka." Theknoloji ea Bokaholimo le Liaparo, 428, 127944.

5. Johnson, MR, le ba bang. (2023). "Gradient zirconium oxide coatings bakeng sa ts'ebetso e ntlafalitsoeng ea implant: tlhahlobo ea lipatlisiso tsa hajoale le litebello tsa nako e tlang." Lintho tse phelang, 294, 121859.

6. Zhang, L., le ba bang. (2023). "Liaparo tsa zirconium oxide tse sebetsang hantle bakeng sa li-implants tsa bongaka: Ho kopanya limolek'hule tsa bioactive bakeng sa ntlafatso ea osseointegration." ACS Biomaterials Science & Engineering, 9(5), 2156-2170.